Some pharmacologic effects of the choline ester of chaulmoogric acid

The choline ester of chaulmoogric acid has a small but definite muscarine-like activity, slightly greater than that of molescularly equivalent amounts of choline. In addition it has direct harmful effects upon tissues. A fraction of the ester may be rapidly hydrolized to form choline chaulmoograte. Chaulmoogrylcholine is unsuited for antileprosy use since its toxicity precludes administration of significant amounts of chaulmoogric acid in this form.

A introdução e a aclimação de plantas contra a lepra / The introduction and acclimatization of plants against leprosy

Os novos methodos de luta contra a lepra com os oleos de "chaulmoogra" e seus derivados, em particular nas Indias, nas Ilhas Hawaii e em Molokai (trabalhos da Irmn Marie Susane) provaram que uma porcentagem notavel de hansenianos em estado adiantado, podia ser curada e que, em inicio, "eram curados cento por cento".

Uber einige carbons„ureester de chaulmoogryl und hydnocarpylalkohols / Some carboxylic acid ester de chaulmoogryl and hydnocarpylalkohols

Wahrend man sich fruher darauf beschrankte, die in den verschiedenen Flacourtiaceenolen enthaltenen therapeutisch wirksamen Cyclofettsauren in Form ihrer Salze oder Ester wie Athyl und Benzylester klinisch zu verwenden, wird seit Jahren von einigen 1)2)3) versucht, durch chemische Modellierung der Chaulmoogra- und der Hydnocarpussaure sowie durch Synthese ahnlich gebauter Verbindungen zu maximal wirksamen Heilmitteln gegen die Lepra zu gelangen.